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Clinical trial information


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Area under investigation,Metastatic urothelial carcinoma=true,Muscle Invasive Urothelial Carcinoma

DESTINY-PanTumor02 trial overview

Tumor

Early-stage NSCLC adenocarcinoma following complete surgical resection (R0) that is ctDNA-positive or has high-risk pathological features

Trial Identifier

NCT06564844

Phase

III

Stage

Treatment-naïve Stage I

Regimen

Dato-DXd + rilvegostomig; rilvegostomig; SoC; abc

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fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of the world.

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TROPION-Urothelial04 trial overview

Tumor

High-risk muscle invasive urothelial carcinoma

Trial Identifier

NCT07720284

Phase

III

Regimen

Dato-DXd + rilvegostomig; Dato-DXd; nivolumab or durvalumab or EV + pembrolizumab

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TROPION-PanTumor03 trial overview

Tumor

Advanced solid tumors (endometrial, gastric, mCRPC, ovarian, colorectal, metastatic urothelial carcinoma, BTCs)

Trial Identifier

NCT05489211

Phase

II

Regimen

Dato-DXd; Dato-DXd + capecitabine or 5-FU; Dato-DXd + prednisone or prednisolone; Dato-DXd + carboplatin + bevacizumab followed by Dato-DXd + bevacizumab; Dato-DXd + bevacizumab + (5-FU + leucovorin or capecitabine); Dato-DXd+ 5-FU/leucovorin or capecitabine + bevacizumab; Dato-DXd + rilvegostomig or carboplatin/cisplatin

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Some compounds herein refer to selected AstraZeneca pipeline products still under development. AstraZeneca pipeline products are investigational products and, as such, are not approved by the US Food & Drug Administration (FDA), the European Medicines Agency (EMA) or any other regulatory agency for the uses under investigation. Information regarding these investigational products should, under no circumstances, be regarded as a recommendation for their use or of their safety or efficacy.

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Veeva ID: Z4-84958 US-109129 DE-92568 Last Updated October 20263/26
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