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Area under investigation,EGFRm NSCLC=true,Mesothelioma,MET-driven NSCLC,NSCLC,SCLC

ADAURA2 trial overview

Tumor

EGFRm Stage IA2-IA3 NSCLC following complete tumor resection

Trial Identifier

NCT05120349

Phase

III

Stage

Resectable Stage I-III

Regimen

Osimertinib; placebo

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ADRIATIC trial overview

Tumor

Limited stage SCLC not progressed following cCRT

Trial Identifier

NCT03703297

Phase

III

Regimen

Durvalumab; durvalumab + tremelimumab; placebo

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ALTAIR trial overview

Tumor

Advanced or metastatic squamous or non-squamous NSCLC

Trial Identifier

NCT06996782

Phase

Ib/II

Stage

Stage IV

Regimen

Rilvegostomig + ramucirumab + PBC (squamous histology); rilvegostomig + ramucirumab + chemotherapy OR rilvegostomig + chemotherapy (for non-squamous histology)

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ARTEMIDE-01 trial overview

Tumor

Advanced or metastatic NSCLC, 1L/2L

Trial Identifier

NCT04995523

Phase

I/II

Stage

Metastatic, ≥1L

Regimen

Rilvegostomig

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ARTEMIDE-Lung02 trial overview

Tumor

Advanced or metastatic squamous NSCLC, 1L

Trial Identifier

NCT06692738

Phase

III

Stage

Metastatic, 1L

Regimen

Rilvegostomig + platinum based CT; pembrolizumab + platinum-based CT

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ARTEMIDE-Lung03 trial overview

Tumor

Advanced or metastatic non-squamous NSCLC, 1L

Trial Identifier

NCT06627647

Phase

III

Stage

Metastatic, 1L

Regimen

Rilvegostomig + platinum based doublet CT; pembrolizumab + platinum-based doublet CT

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ARTEMIDE-Lung04 trial overview

Tumor

Advanced or metastatic NSCLC, 1L

Trial Identifier

NCT06868277

Phase

III

Stage

Metastatic, 1L

Regimen

Rilvegostomig; pembrolizumab

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AVANZAR trial overview

Tumor

Advanced/metastatic NSCLC without actionable genomic alterations

Trial Identifier

NCT05687266

Phase

III

Stage

Advanced/metastatic NSCLC, 1L

Regimen

Dato-DXd + durvalumab + carboplatin; histologic-specific therapy (pembrolizumab + CT)

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DESTINY-Lung03 trial overview

Tumor

Unresectable locally advanced/metastatic non-squamous HER2 overexpressing NSCLC

Trial Identifier

NCT04686305

Phase

Ib

Stage

Metastatic, ≥1L

Regimen

T-DXd + durvalumab + (cisplatin/carboplatin/pemetrexed); T-DXd; T-DXd + volrustomig ± carboplatin; T-DXd + rilvegostomig ± carboplatin

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fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world.

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DESTINY-Lung04 trial overview

Tumor

Unresectable, locally advanced, or metastatic NSCLC with HER2 Exon 19 or 20 mutations

Trial Identifier

NCT05048797

Phase

III

Stage

Metastatic, 1L

Regimen

T-DXd; SoC (cisplatin or carboplatin + pemetrexed + pembrolizumab)

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fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world.

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DESTINY-Lung06 trial overview

Tumor

Locally advanced unresectable, or metastatic HER2 overexpressing and PD-L1 TPS <50% nonsquamous NSCLC

Trial Identifier

NCT06899126

Phase

III

Regimen

T-DXd + pembrolizumab; pembrolizumab + pemetrexed + platinum-based chemotherapy (cisplatin or carboplatin)

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fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world. This study is sponsored by Daiichi Sankyo, Inc.

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DS8201-A-U106 trial overview

Tumor

Locally advanced/metastatic HER2-positive breast cancer (as per ASCO-CAP guidelines), HER2-low breast cancer (IHC 1+ or IHC 2+/ISH-), HER2-expressing NSCLC (IHC 1+, 2+, or 3+), and HER2-mutant NSCLC

Trial Identifier

NCT04042701

Phase

Ib

Regimen

T-DXd + pembrolizumab

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fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world. This study is sponsored by Daiichi Sankyo, Inc.

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eVOLVE-01 trial overview

Tumor

NSCLC

Trial Identifier

NCT06448754

Phase

II

Regimen

Volrustomig (different doses) + chemotherapy; volrustomig + ramucirumab + chemotherapy

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eVOLVE-02 trial overview

Tumor

Advanced or metastatic tumors (Cervical, HNSCC, pleural mesothelioma, and ESCC)

Trial Identifier

NCT06535607

Phase

II

Regimen

Volrustomig monotherapy; volrustomig + chemotherapy

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eVOLVE-Meso trial overview

Tumor

Advanced unresectable pleural mesothelioma

Trial Identifier

NCT06097728

Phase

III

Regimen

Volrustomig + carboplatin + pemetrexed; investigator's choice of standard care

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FONTANA trial overview

Tumor

Advanced solid tumors

Trial Identifier

NCT05797168

Phase

I/IIa

Regimen

Torvutatug samrotecan monotherapy; torvutatug samrotecan + saruparib; torvutatug samrotecan + bevacizumab; torvutatug samrotecan + carboplatin ± bevacizumab; torvutatug samrotecan + palacaparib

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LIBRA trial overview

Tumor

Locally advanced/metastatic NSCLC

Trial Identifier

NCT07098338

Phase

II

Stage

Stage IV

Regimen

Rilvegostomig ± ramucirumab; Dato‑DXd + ramucirumab ± rilvegostomig

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NeoADAURA trial overview

Tumor

EGFRm resectable stage II-IIIB N2 NSCLC

Trial Identifier

NCT04351555

Phase

III

Stage

Resectable Stage II-III

Regimen

Osimertinib; PtCh ± osimertinib

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NeoCOAST-2 trial overview

Tumor

Resectable stage IIA to IIIB NSCLC (EGFR/ALK wild-type)

Trial Identifier

NCT05061550

Phase

II

Stage

Resectable disease (IIA to IIIB)

Regimen

Oleclumab + durvalumab + PtCh; monalizumab + durvalumab + PtCh; volrustomig (dose exploration) + PtCh; Dato-DXd + durvalumab + single agent platinum; AZD0171 + durvalumab + PtCh; rilvegostomig + PtCh; Dato-DXd + rilvegostomig + single agent platinum

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ORCHARD trial overview

Tumor

Advanced/metastatic EGFRm NSCLC with disease progression following 1L therapy with osimertinib

Trial Identifier

NCT03944772

Phase

II

Stage

Advanced/metastatic NSCLC

Regimen

Osimertinib + (savolitinib or gefitinib or necitumumab or alectinib or selpercatinib or pemetrexed + PtCh or selumetinib or Dato-DXd); durvalumab + pemetrexed + carboplatin; durvalumab + etoposide + PtCh

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PACIFIC-4 trial overview

Tumor

Unresected Stage I/II, lymph node-negative NSCLC including tumors harboring a sensitizing EGFR mutation

Trial Identifier

NCT03833154

Phase

III

Stage

Unresected Stage I-II

Regimen

SBRT + placebo; SBRT + durvalumab; SBRT followed by osimertinib

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PACIFIC-9 trial overview

Tumor

Unresectable stage III NSCLC not progressed following definitive platinum-based cCRT

Trial Identifier

NCT05221840

Phase

III

Stage

Unresectable Stage III

Regimen

Durvalumab + oleclumab; durvalumab + monalizumab; durvalumab + placebo

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PETRA trial overview

Tumor

Advanced solid tumors (advanced/metastatic ovarian cancer, HR+/HER2- breast cancer, TNBC, pancreatic cancer, prostate cancer, NSCLC, SCLC, gastric cancer, biliary cancer, cervical cancer, endometrial cancer, CRC, bladder cancer)

Trial Identifier

NCT04644068

Phase

I/IIa

Regimen

Saruparib; saruparib + paclitaxel; saruparib + carboplatin ± paclitaxel; saruparib + T-DXd; saruparib + Dato-DXd; saruparib + camizestrant

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fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world.

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SAFFRON trial overview

Tumor

Locally advanced or metastatic EGFRm, MET overexpressed and/or amplified (IHC3+/≥90% and/or FISH10+) NSCLC that progressed on 1L or 2L osimertinib therapy

Trial Identifier

NCT05261399

Phase

III

Stage

Metastatic, ≥2L

Regimen

Osimertinib + savolitinib; pemetrexed + PtCh

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Savolitinib, partnered with HUTCHMED

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SAVANNAH trial overview

Tumor

EGFRm and MET overexpressed and/or amplified (IHC3+/≥90% and/or FISH10+), locally advanced or metastatic NSCLC that progressed following 1L osimertinib treatment

Trial Identifier

NCT03778229

Phase

II

Stage

Metastatic, ≥2L

Regimen

Osimertinib + savolitinib; placebo + savolitinib

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Savolitinib, partnered with HUTCHMED

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TROPION-Lung04 trial overview

Tumor

Advanced/metastatic NSCLC without actionable genomic alterations and with/without previous treatment

Trial Identifier

NCT04612751

Phase

Ib

Stage

Advanced/metastatic NSCLC

Regimen

Dato-DXd + durvalumab ± carboplatin; Dato-DXd + rilvegostomig ± carboplatin; Dato-DXd + sabestomig

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TROPION-Lung07 trial overview

Tumor

Treatment-naïve patients with nonsquamous advanced/metastatic NSCLC without actionable genomic alterations and PD-L1 TPS <50%

Trial Identifier

NCT05555732

Phase

III

Stage

Advanced/metastatic NSCLC

Regimen

Dato-DXd + pembrolizumab ± PtCh; pembrolizumab + pemetrexed + PtCh

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This study is sponsored by Daiichi Sankyo, Inc.

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TROPION-Lung08 trial overview

Tumor

Treatment naive patients with advanced/metastatic NSCLC without actionable genomic alterations and with high PD-L1 expression (TPS ≥50%)

Trial Identifier

NCT05215340

Phase

III

Stage

Advanced/metastatic NSCLC

Regimen

Dato-DXd + pembrolizumab; pembrolizumab

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This study is sponsored by Daiichi Sankyo, Inc.

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TROPION-Lung10 trial overview

Tumor

Advanced/metastatic nonsquamous NSCLC without actionable genomic alterations and with high PD-L1 expression (TC ≥ 50%), 1L

Trial Identifier

NCT06357533

Phase

III

Stage

Advanced/metastatic NSCLC

Regimen

Dato-DXd + rilvegostomig; rilvegostomig; pembrolizumab

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TROPION-Lung14 trial overview

Tumor

Advanced/metastatic, or recurrent, EGFRm (Ex19del and/or L858R) nonsquamous NSCLC, 1L

Trial Identifier

NCT06350097

Phase

III

Stage

Advanced/metastatic NSCLC

Regimen

Osimertinib + Dato-DXd; osimertinib

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TROPION-Lung15 trial overview

Tumor

Advanced/metastatic EGFRm NSCLC with disease progression on prior osimertinib therapy

Trial Identifier

NCT06417814

Phase

III

Stage

Advanced/metastatic NSCLC

Regimen

Dato-DXd + osimertinib; Dato-DXd; pemetrexed + carboplatin or cisplatin followed by pemetrexed

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TROPION-Lung17 trial overview

Tumor

TROP2 NMR positive advanced/metastatic nonsquamous NSCLC without actionable genomic alterations

Trial Identifier

NCT07291037

Phase

III

Stage

Advanced/metastatic NSCLC

Regimen

Dato-DXd; docetaxel

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TROPION-PanTumor01 trial overview

Tumor

Advanced solid tumors including advanced/metastatic NSCLC, TNBC, HR-positive/HER2-negative breast cancer, HER2-low breast cancer, and other solid tumors

Trial Identifier

NCT03401385

Phase

I

Regimen

Dato-DXd

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This study is sponsored by Daiichi Sankyo, Inc.

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Veeva ID: Z4-84958 US-109129 DE-92568 Last Updated October 20263/26
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