BACK

Breast > HER2-low breast cancer

Clinical trial information


Select trial for more information

Area under investigation,BRCAm or PALB2m breast cancer,HER2 IHC 0 metastatic breast cancer,HER2-low breast cancer=true,HER2-positive breast cancer,HR-positive/HER2-negative breast cancer,TNBC

BLUESTAR trial overview

Tumor

Advanced solid tumors (breast cancer, BTCs, ovarian cancer, endometrial cancer, squamous NSCLC)

Trial Identifier

NCT05123482

Phase

I/IIa

Regimen

Puxitatug samrotecan monotherapy; puxitatug samrotecan + rilvegostomig; puxitatug samrotecan + rilvegostomig + palacaparib

Visit ct.gov
Go

CAMBRIA-1 trial overview

Tumor

HR+/HER2- eBC with intermediate/high risk for disease recurrence and post definitive locoregional therapy and adjuvant ET for ≥2 and up to 5 years

Trial Identifier

NCT05774951

Phase

III

Regimen

Camizestrant; standard endocrine therapy of investigator's choice (aromatase inhibitors or tamoxifen)

Visit ct.gov
Go

CAMBRIA-2 trial overview

Tumor

HR+/HER2- eBC with intermediate-high or high risk for disease recurrence after completion of definitive locoregional therapy (with or without chemotherapy)

Trial Identifier

NCT05952557

Phase

III

Regimen

Camizestrant ± abemaciclib; standard endocrine therapy of investigator's choice ± abemaciclib

Visit ct.gov
Go

CAPItello-292 trial overview

Tumor

HR+/HER2-negative locally advanced or metastatic breast cancer relapsing on or within 12 months of completing adjuvant ET

Trial Identifier

NCT04862663

Phase

Ib/III

Regimen

Phase Ib - capivasertib + fulvestrant + CDK4/6i (palbociclib or ribociclib or abemaciclib); Phase III - fulvestrant + (palbociclib or ribociclib) ± capivasertib

Visit ct.gov
Go

CYCAD-1 trial overview

Tumor

HR+/HER2- advanced breast cancer, metastatic high-grade serous ovarian cancer

Trial Identifier

NCT06188520

Phase

I/IIa

Regimen

AZD8421; AZD8421 + camizestrant + abemaciclib; AZD8421 + camizestrant + ribociclib; AZD8421 + camizestrant + palbociclib

Visit ct.gov
Go

DESTINY-Breast09 trial overview

Tumor

HER2+ Advanced or metastatic breast cancer

Trial Identifier

NCT04784715

Phase

III

Regimen

T-DXd  ± pertuzumab; trastuzumab + pertuzumab + a taxane (investigator's choice of docetaxel or paclitaxel)

Visit ct.gov

fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world.

Go

DESTINY-Breast15 trial overview

Tumor

HER2-low or HER2 IHC 0 unresectable or metastatic breast cancer

Trial Identifier

NCT05950945

Phase

III

Regimen

T-DXd

Visit ct.gov

fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world.

Go

EvoPAR-Breast01 trial overview

Tumor

Advanced HR+/HER2- breast cancer with germline or somatic mutations in BRCA1/2 or PALB2 genes

Trial Identifier

NCT06380751

Phase

III

Regimen

Saruparib + camizestrant; physician’s choice CDK4/6i + physician’s choice endocrine therapy; physician’s choice CDK4/6i + camizestrant

Visit ct.gov
Go

PETRA trial overview

Tumor

Advanced solid tumors (advanced/metastatic ovarian cancer, HR+/HER2- breast cancer, TNBC, pancreatic cancer, prostate cancer, NSCLC, SCLC, gastric cancer, biliary cancer, cervical cancer, endometrial cancer, CRC, bladder cancer)

Trial Identifier

NCT04644068

Phase

I/IIa

Regimen

Saruparib; saruparib + paclitaxel; saruparib + carboplatin ± paclitaxel; saruparib + T-DXd; saruparib + Dato-DXd; saruparib + camizestrant

Visit ct.gov

fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world.

Go

SERENA-4 trial overview

Tumor

HR+/HER2- advanced/metastatic breast cancer, 1L

Trial Identifier

NCT04711252

Phase

III

Regimen

Camizestrant + palbociclib; anastrozole + palbociclib

Visit ct.gov
Go

SubQ (NCT07015697) trial overview

Tumor

HER2-expressing metastatic solid tumors

Trial Identifier

NCT07015697

Phase

I

Regimen

Subcutaneous T-DXd + hyaluronidase

Visit ct.gov

fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world. This study is sponsored by Daiichi Sankyo, Inc.

Go

TROPION-Breast03 trial overview

Tumor

TNBC (Stage I-III) who have residual invasive disease in the breast and/or axillary lymph nodes at surgical resection following neoadjuvant systemic therapy

Trial Identifier

NCT05629585

Phase

III

Stage

Stage I-III

Regimen

Dato-DXd ± durvalumab; investigator's choice of therapy (capecitabine or pembrolizumab or capecitabine + pembrolizumab)

Visit ct.gov
Go

TROPION-Breast04 trial overview

Tumor

Histologically confirmed Stage II or III primary invasive TNBC or HR-low/HER2- BC

Trial Identifier

NCT06112379

Phase

III

Stage

Stage II-III

Regimen

Neoadjuvant Dato-DXd + durvalumab followed by adjuvant durvalumab ± olaparib (if gBRCAm) or CT; neoadjuvant pembrolizumab + CT followed by adjuvant pembrolizumab ± olaparib or capecitabine

Visit ct.gov
Go

TROPION-Breast05 trial overview

Tumor

Locally recurrent inoperable or metastatic PD-L1-positive TNBC not previously treated with chemotherapy or targeted systemic anticancer therapy in this setting

Trial Identifier

NCT06103864

Phase

III

Stage

Stage IV

Regimen

Dato-DXd + durvalumab; investigator's choice of CT (paclitaxel, nab-paclitaxel, or gemcitabine + carboplatin) with pembrolizumab; Dato-DXd monotherapy

Visit ct.gov
Go

TROPION-Breast06 trial overview

Tumor

HR-positive/HER2 IHC 0, locally advanced inoperable or mBC refractory to ET

Trial Identifier

NCT07205822

Phase

IIIb

Stage

Stage IV

Regimen

Dato-DXd

Visit ct.gov
Go

TROPION-PanTumor01 trial overview

Tumor

Advanced solid tumors including advanced/metastatic NSCLC, TNBC, HR-positive/HER2-negative breast cancer, HER2-low breast cancer, and other solid tumors

Trial Identifier

NCT03401385

Phase

I

Regimen

Dato-DXd

Visit ct.gov

This study is sponsored by Daiichi Sankyo, Inc.

Go

Some compounds herein refer to selected AstraZeneca pipeline products still under development. AstraZeneca pipeline products are investigational products and, as such, are not approved by the US Food & Drug Administration (FDA), the European Medicines Agency (EMA) or any other regulatory agency for the uses under investigation. Information regarding these investigational products should, under no circumstances, be regarded as a recommendation for their use or of their safety or efficacy.

This site is intended for US Healthcare Professionals.

Veeva ID: Z4-84958 US-109129 DE-92568 Last Updated October 20263/26
©2026 AstraZeneca. All rights reserved.