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Prostate Trials

Clinical trial information


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Area under investigation=true,Localized prostate cancer,mCRPC,mHSPC,Metastatic prostate cancer

ACTIVATED-4-PC trial overview

Tumor

mCRPC

Trial Identifier

NCT07192614

Phase

I/II

Regimen

AZD6621 monotherapy [administration route 1 (module 1) or administration route 2 (module 2) at recommended dose for expansion 1 and 2 (RDE1 and RDE2)] administration route 1 (module 1) or administration route 2 (module 2) at recommended dose for expansion 2 (RDE2)

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AlphaBreak trial overview

Tumor

PSMA-positive mCRPC

Trial Identifier

NCT06402331

Phase

II

Regimen

(225Ac) zadavotide guraxetan monotherapy, IV administration

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This study is sponsored by Fusion Pharmaceuticals Inc.

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ANDROMEDA trial overview

Tumor

Metastatic prostate cancer

Trial Identifier

NCT07336446

Phase

I/II

Regimen

AZD9750 monotherapy; AZD9750 + saruparib;

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APOLLO trial overview

Tumor

mCRPC with prior ARPI and taxane therapy

Trial Identifier

NCT06267729

Phase

I/II

Regimen

AZD0754 (STEAP2 CAR-T) + cyclophosphamide + fludarabine (lymphocyte depleting regimen)

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ASCERTAIN trial overview

Tumor

Window of Opportunity (WOO) study in localized prostate cancer deemed suitable for radical prostatectomy

Trial Identifier

NCT05938270

Phase

I

Regimen

Saruparib; darolutamide; saruparib + darolutamide; no treatment arm

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CRIUS-1 trial overview

Tumor

Adenocarcinoma of the prostate or neuroendocrine differentiated prostate cancer

Trial Identifier

NCT07529717

Phase

I/II

Regimen

AZD8359

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EvoPAR-Prostate01 trial overview

Tumor

mHSPC de novo or recurrent

Trial Identifier

NCT06120491

Phase

III

Regimen

Saruparib + ARPI; placebo + ARPI

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EvoPAR-Prostate02 trial overview

Tumor

High-risk BRCAm prostate cancer

Trial Identifier

NCT06952803

Phase

III

Regimen

Saruparib + physician’s choice ADT; placebo + physician’s choice ADT; saruparib + physician’s choice ADT + abiraterone (and prednisone/prednisolone); placebo + physician’s choice ADT + abiraterone (and prednisone/prednisolone)

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PETRA trial overview

Tumor

Advanced solid tumors (advanced/metastatic ovarian cancer, HR+/HER2- breast cancer, TNBC, pancreatic cancer, prostate cancer, NSCLC, SCLC, gastric cancer, biliary cancer, cervical cancer, endometrial cancer, CRC, bladder cancer)

Trial Identifier

NCT04644068

Phase

I/IIa

Regimen

Saruparib; saruparib + paclitaxel; saruparib + carboplatin ± paclitaxel; saruparib + T-DXd; saruparib + Dato-DXd; saruparib + camizestrant

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fam-trastuzumab deruxtecan-nxki in US only; trastuzumab deruxtecan in other regions of world.

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PETRANHA trial overview

Tumor

Metastatic prostate cancer (mCRPC or mHSPC)

Trial Identifier

NCT05367440

Phase

I/IIa

Regimen

Saruparib + enzalutamide; saruparib + abiraterone acetate; saruparib + darolutamide; saruparib + apalutamide

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PROSPECTOR trial overview

Tumor

Metastatic prostate cancer

Trial Identifier

NCT07590934

Phase

Ib/​II

Regimen

Escalating dose levels of palacaparib + (225Ac) zadavotide guraxetan; selected dose of palacaparib + (225Ac) zadavotide guraxetan; (225Ac) zadavotide guraxetan monotherapy; docetaxel

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SEACLIFF trial overview

Tumor

mCRPC

Trial Identifier

NCT07181161

Phase

I/IIa

Regimen

AZD0516 monotherapy; AZD0516 + palacaparib (AZD0516 will be administered via IV)

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NCT06879041 trial overview

Tumor

Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Trial Identifier

NCT06879041

Phase

I

Regimen

AZD2284; AZD2287; AZD2275

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TROPION-PanTumor03 trial overview

Tumor

Advanced solid tumors (endometrial, gastric, mCRPC, ovarian, colorectal, metastatic urothelial carcinoma, BTCs)

Trial Identifier

NCT05489211

Phase

II

Regimen

Dato-DXd; Dato-DXd + capecitabine or 5-FU; Dato-DXd + prednisone or prednisolone; Dato-DXd + carboplatin + bevacizumab followed by Dato-DXd + bevacizumab; Dato-DXd + bevacizumab + (5-FU + leucovorin or capecitabine); Dato-DXd+ 5-FU/leucovorin or capecitabine + bevacizumab; Dato-DXd + rilvegostomig or carboplatin/cisplatin

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VECTRA-01 trial overview

Tumor

PSMA-positive metastatic castration-resistant prostate cancer

Trial Identifier

NCT07611110

Phase

III

Regimen

(225Ac) zadavotide guraxetan; active comparator: investigator's choice of cabazitaxel, abiraterone, enzalutamide, apalutamide, darolutamide, rezvilutamide, radium-223

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Some compounds herein refer to selected AstraZeneca pipeline products still under development. AstraZeneca pipeline products are investigational products and, as such, are not approved by the US Food & Drug Administration (FDA), the European Medicines Agency (EMA) or any other regulatory agency for the uses under investigation. Information regarding these investigational products should, under no circumstances, be regarded as a recommendation for their use or of their safety or efficacy.

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Veeva ID: Z4-84958 US-109129 DE-92568 Last Updated October 20263/26
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